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KMID : 1123920100240020272
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 2 p.272 ~ p.277
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( Anticancer Effects of Egg White Combined-Chalcanthite on NCI-H460 Tumor Regression Model )
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Choi Eun-A
Kim Jung-Keun
Kim Kyung-Soon
Choi Jung-Eun
Cho Chong-Kwan
Lee Yeon-Weol
Yoo Hwa-Seung
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Abstract
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This experimental study was performed to investigate the antitumor effect of Egg white combined-Chalcanthite (InSan 4, IS4) in xenografted nude mice with NCI-H460 human lung cancer cell. We cultured NCI-H460 cell lines and xenografted them on nude mice. These mice were divided into 3 groups; group with dose of 45 mg/kg IS4 orally, group with dose of 90 mg/kg IS4 orally, and the control group. They had been raised and treated for 28 days. We checked their body weight, tumor weight and volume twice a week, and their absolute organ weight, microhistological observation and biochemical blood analysis at the final day by sacrificing them. We also calculated their tumor inhibition rate (IR), mean survival time and percent increase in life span (% ILS). In this study, we observed that all of the IS4 treated mice have tumor regression, dosage-dependently, compared to the control group. Tumor weight and volume of high dose treated mice were smallest. IR increased in IS4 in a dose-dependent manner. Mean survival time and percent increase in life span (% ILS) in high-dose IS4 treatment group were the highest of the three groups. There was no significant difference in biochemical blood analysis, alanine phopsphatase (ALP), Calcium, creatinine (CRE), alanine transferase (ALT), and aspartate transaminase (AST) levels. The urea nitrogen (UN) level results significantly decreased by IS4 45 and 90 mg/kg (IS4 45 mg/kg, IS4 90 mg/kg, p<0.01). IS4 may have potential anti-tumor effect in a solid tumor induced by NCI-H460 without remarkable side effects.
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KEYWORD
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egg white combined-chalcanthite, NCI-H460 cell, anti-tumor effect, xenografted nude mice
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